Описание
Oxaliplatin CAS 61825-94-3 Quick Details
| Химическое название: | Oxaliplatin |
| Другое название: | Trans-l-diaminocyclohexane oxalatoplatinum; Eloxatin; Oxaliplatin and capecitabine |
| CAS: | 61825-94-3 |
| EINECS: | 621-248-1 |
| Тип: | Pharmaceutical raw materials; Pharmaceutical, agriculture, dye intermediates |
| Молекулярная формула: | C8H12N2O4Pt |
| Молекулярная масса: | 395.28 |
Oxaliplatin CAS 61825-94-3 Chemical Properties
| альфа | +74.5-78.0 (D/20)(c=0.5,H2O) |
| температура хранения. | 2-8°C |
| растворимость | Slightly soluble in water, very slightly soluble in methanol, practically insoluble in anhydrous ethanol. |
| форма | solid |
| Растворимость в воде | Soluble in water with heating and/or sonication |
| Стабильность: | Stable. Store cool. Incompatible with oxidizing agents. |
Oxaliplatin Uses
- The third generation platinum complex. An anti-tumor representative with anti-colorectal cancer task. Cytotoxicity follows the formation of DNA adducts. Antitumor.
- Oxaliplatin is a platinum-based antineoplastic drug that works by specifically creating DNA adducts in cancer cells, protecting against DNA replication as well as transcription that lead to cell death.
- Oxaliplatin is cytotoxic in numerous cell lines consisting of colon, ovarian and also lung cancer cells with IC50 values of 0.5-240, 0.12-19.8 as well as 2.6-6.1 μM, respectively.
- Via its general cytotoxic results, oxaliplatin has antitumor task versus advanced intestines cancer cells, normally in combination with fluorouracil as well as leucovorin, referred to as FOLFOX.
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