Paeoniflorin CAS 23180-57-6

Peony is derived from the dried root of the perennial herbaceous plant in the Paeoniaceae family. This herb has a bitter, sour taste and is slightly cold in nature. In traditional Chinese medicine, it targets the liver and spleen meridians, providing various benefits such as:

• Calming the liver and relieving pain
• Nourishing blood and regulating menstruation
• Astringing yin and stopping sweating

Commonly, peony is used to address conditions like headaches, dizziness, rib pain, abdominal pain, cramps, and irregular menstruation, as well as symptoms like spontaneous perspiration and night sweats.

What is Paeoniflorin?

Paeoniflorin is the primary active component extracted from peony. It has numerous physiological benefits, including anti-inflammatory, immune-boosting, liver-protective, and analgesic effects.

Paeoniflorin has a molecular formula of C23H28O11 and belongs to the monoterpenoid compound category. At room temperature, it appears as a white amorphous powder that readily absorbs moisture and is sensitive to heat, acid, and alkali.

Pharmacological Effects

Research has demonstrated that paeoniflorin offers a wide range of pharmacological benefits, such as:

• Antidepressant
• Anti-inflammatory
• Analgesic
• Anti-tumor
• Liver protection
• Nerve protection
• Immune regulation
• Sedative and hypnotic effects

Paeoniflorin works by activating adenosine A1 receptors in the kidneys, which can reverse guanidine-induced antihypertensive effects.

Clinical Applications

This compound can protect tissue cells from oxidative stress, inhibit astrocyte activation, and enhance neuroprotection. It effectively counters damage to dopaminergic nerve cells, improving conditions like bradykinesia. Consequently, paeoniflorin shows promise in treating neurodegenerative diseases such as Alzheimer’s and Parkinson’s, as well as epilepsy.

Additionally, it may combat tumors and autoimmune diseases, including rheumatoid arthritis and ankylosing spondylitis. Animal studies suggest that it can significantly lower blood sugar levels and offers protective benefits for heart and lung cells.

Conclusion

Paeoniflorin, the active ingredient in peony, stands out for its diverse therapeutic properties, making it a valuable component in traditional and modern medicinal practices. Its wide-ranging effects underscore its potential in treating various health conditions.