Description
What is N-(Trimethylsilyl)acetamide CAS 13435-12-6
N-(Trimethylsilyl)acetamide (TMSA) is a chemical reagent used in organic synthesis to introduce a trimethylsilyl (TMS) group to compounds. It is primarily used for protecting functional groups, improving stability, and facilitating reactions in chemical synthesis and analysis.
Chemical Properties
| Property | Value |
| Molecular Formula | C5H13NOS |
| Molar Mass | 119.23 g/mol |
| Appearance | Colorless liquid |
| Boiling Point | 142°C |
| Melting Point | -23°C |
| Density | 0.91 g/cm³ |
| Flash Point | 41°C |
| Solubility | Soluble in organic solvents (e.g., dichloromethane, ether) |
| Storage Conditions | Store in a cool, dry place away from moisture and incompatible materials. |
| Vapor Pressure | 0.03 mmHg (at 25°C) |
| Reactivity | Sensitive to water; reacts with moisture to form silanol byproducts. |
Application
N-(Trimethylsilyl)acetamide (TMSA) is primarily used as a reagent in organic synthesis. It is often employed in silylation reactions to protect amines and hydroxyl groups in the preparation of other compounds. TMSA is also used in chemical analysis for derivatization in chromatography, helping to improve the detection of certain molecules. Additionally, it can be used in the production of silicone-based compounds and other specialty chemicals.
Packing
25kgs/drum, 9tons/20’container
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