Description
Isonicotinic acid Quick Details
| Chemical Name: | Isonicotinic acid |
| Other Name: | 4-Pyridine hydroxy acid; 4-Pyridine acid; Pyridine-4-hydroxy acid; 4-pyridinecarboxylic acid; Γ-picolinic acid; Pyridine-4-carboxylic acid |
| CAS: | 55-22-1 |
| EINECS: | 200-228-2 |
| Type: | Pharmaceutical raw materials(APIs) |
| Molecular Formula: | C6H5NO2 |
| Molecular Weight: | 123.11 |
Isonicotinic acid Chemical Properties
| Melting point | ≥300 °C (lit.) |
| Boiling point | 260 °C (15 mmHg) |
| Density | 1,47g/cm |
| Refractive index | 1.5423 (estimate) |
| Fp | 260°C/15mm |
| Storage temp. | no restrictions. |
| Solubility | 6g/l |
| Pka | 4.96(at 25℃) |
| Form | powder |
| Color | yellow to tan |
| PH | 3-4 (6g/l, H2O, 20℃)(saturated solution) |
| Water Solubility | 5.2 g/L (20 ºC) |
Isonicotinic acid Uses
- Isnicotinic acid is a widely used intermediate. Mainly used as isoniazid (ramiphen), terfenadine, isoniacic acid and other first-line anti-tuberculosis drugs raw materials, can also be used as preservatives, electroplating additives, photosensitizers. Resin stabilizer, PVC heat stabilizer, non-ferrous metal flotation agent, etc.
- Isoniazid can be obtained by condensation and melting dehydration of isoniazid and hydrazine hydrate. Isoniazid has good antibacterial effect on mycobacterium tuberculosis, good efficacy, small dosage, relatively low toxicity. It is used to treat all forms of tuberculosis. It can also be used for advanced tuberculous meningitis and other extrapulmonary tuberculosis, during the period of dissolution and spread, and during the period of improved absorption. These preparations include tablets and injections.
- It is used as a pharmaceutical intermediate, mainly for the production of anti-tuberculosis drug isoniazid, and also for the synthesis of derivatives such as amides, hydrazides, and esters.
- Isonicotinic acid, also known as pyridine 4-carboxylate, is an intermediate of the plant growth regulator Trexamine, as well as an intermediate of isoniazid, a medicinal anti-tuberculosis drug.
- In addition, isonicotinic acid can also be used to synthesize other organic compounds or prepare chemical materials. Examples of its applications are as follows:
For the synthesis of 4-chloromethylpyridine hydrochloride
Used to prepare a high temperature resistant waterproof material
Used to prepare a vehicle lubricating oil
For the preparation of a conductive textile fiber
Used to prepare a high temperature resistant waterproof material
Used to prepare a vehicle lubricating oil
For the preparation of a conductive textile fiber
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