Palmidrol CAS 544-31-0

Description

Palmidrol Quick Details

Chemical Name: Palmidrol

CAS NO: 544-31-0

Molecular formula: C18H37NO2

Palmidrol Structure:

Molecular weight 299.49

Appearance: White powder

Content: 98%

Typical Properties

Palmidrol: A Natural Anti-Inflammatory and Analgesic Agent

Palmidrol, also known as PEA (Palmitoylethanolamide), is an endogenous fatty acid amide classified as a nuclear transcription factor agonist. It binds to nuclear receptors in the cell nucleus, leading to a variety of biological functions that are beneficial in managing chronic pain and inflammation. Notably, PEA targets peroxisome proliferator-activated receptor alpha (PPAR-α), a critical receptor involved in regulating inflammation and lipid metabolism.

PPAR-α and Fat Metabolism

PPAR-α is one of the three subtypes of the PPAR family, the others being PPAR-β and PPAR-γ. Predominantly expressed in organs and tissues that actively metabolize fats, PPAR-α regulates the transcription of genes involved in fatty acid oxidation. It plays a significant role in lipid uptake, oxidation, and amino acid metabolism. In broader physiological processes, PPAR-α influences hemostasis, inflammation, lipid metabolism disorders, and contributes to conditions such as atherosclerosis and coronary artery disease.

Mechanism of Action and Efficacy in Animal Studies

The mechanism of action of Palmidrol and its efficacy have been extensively validated through animal models of chronic pain and inflammation. For example, in chronic granulomatous pain models, PEA has effectively reduced mechanical pain caused by nerve sprouting. Additionally, PEA prevents the activation of ganglia, demonstrating its dual action as both an anti-inflammatory and analgesic agent. These results suggest that Palmidrol operates through multiple mechanisms to relieve pain and inflammation.

Impact on the Nervous System

In the nervous system, Palmidrol is produced as part of the body’s natural repair mechanism in response to chronic inflammation and pain. In bladder inflammation, PEA has been shown to alleviate pain caused by visceral nerve reflexes. Similarly, in the femoral nerve system, Palmidrol reduces pain perception by influencing peripheral mast cells that contribute to inflammation. By modulating these processes, Palmidrol offers significant potential in treating conditions associated with nerve-related pain.

Packaging and Storage

Packaging: Palmidrol is packaged in paper drums, each containing two plastic bags inside, with a net weight of 25 kg per drum.

Storage: It is crucial to store Palmidrol in a well-sealed container, away from moisture and direct sunlight.

Shelf Life: When properly sealed and stored, Palmidrol retains its efficacy for up to 2 years.

Manufacturing Process (Flow Chart)

1. Palm Oil Mixed with Unsaturated Fatty Acids → Crude Palmitic Acid (via Vacuum Distillation) → Pure Palmitic Acid (via Crystallization) → Palmitoyl Chloride (via Phosgenation Reaction)
2. Crude Palmitoylethanolamide → Purification → Filtration → Re-dissolve in Ethanol → Crystallization → Filtrate Clear Liquid → Crystallization → Filtration → Solid Vacuum Drying → Testing → Packing → Final Product (N-Palmitoylethanolamide)

Palmidrol Applications

1. Anti-Inflammatory: Palmidrol has been shown to bind to nuclear receptors and significantly reduce inflammation. Its primary target is PPAR-α, which regulates key inflammatory pathways in the body.
2. Pain Relief and Neuroprotection: In addition to its anti-inflammatory properties, Palmidrol also offers anti-nociceptive effects (pain relief), neuroprotective properties, and anticonvulsant activity. This makes it useful in a variety of medical conditions, especially those involving chronic pain or neurological damage.
3. Food Additive: As an edible compound, Palmidrol is used as a raw material for food additives, offering additional benefits for enhancing health and wellness.

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