Description
Levosimendan Quick Details
Chemical Name:Levosimendan
CAS: 141505-33-1
Molecular Formula: C14H12N6O
Molecular Weight: 280.28
Chemical Structure:
Appearance:Yellow crystalline powder, odorless, tasteless
Levosimendan Typical Properties
| Item | Specifications | |
| Appearance | Yellow crystalline powder, odorless, tasteless. | |
| Solubility | Sparingly soluble in Methanol and Acetone,slightly solublein ethanol and chloroform,practically insoluble in water. | |
| Identification | byHPLC | The retention times of the major peak of the sample solutioncorresponds to that ofthe standard solution as obtained inthe Assay. |
| byHPLC | The retention times of the major peak of the sample solutioncorresponds to that ofthe standard solution as obtained inthe Dextroisomer. | |
| by IR | Infrared absorption spectrum is consistent with thereference standard map. | |
| Specific rotation | -548℃~ -582℃(drid sobstance) | |
| Clarityandcolorofsolution | Compared with the standard solution , not deeper. | |
| Related substance | A: Largest Singleimpurity<0.2%
B: Total impurities<0.5% |
|
| Water by KF | <1.0 | |
| Residual Solvents by GC | Methanol | <0.3% |
| Isopropanol | <0.5% | |
| Acetone | <0.5% | |
| Acetonitrile | <0.041% | |
| Dioxane | <0.038% | |
| Endotoxin | Less than 20eu/mg | |
| Heavy metals | <15ppm | |
| Ignltion residue | <0.1% | |
| Assay by HPLC | 98.5% to 102.0% (drid sobstance) | |
Levosimendan Usage
1.Levosimendan is an optical isomer of simengtan and is a new positive inotropic drug.
2.Pharmaceutical raw materials.
3. It is a troponin calcium agonist and is indicated for the treatment of acute heart failure.
4. Levosimendan has both calcium ion sensitization activity and potassium channel opening action, so it has both myocardial contractility and anti-ischemia and vasodilation.
5. Clinical studies have confirmed that both cardiac output and vasodilation are reduced, and the heart’s front and rear load is reduced when the heart pump function is improved.
6. Patients who are treated with levosimendan can receive basic drugs such as vasodilators and diuretics.
Levosimendan Packaging and Shipping
Bottle.
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