Description
2-Acetylbutyrolactone CAS 517-23-7 Quick Details
| Chemical Name: | 2-Acetylbutyrolactone |
| Other Name: | Alpa-acetyl-gama-butyl ester; 2-Acetyl-γ-butyrolactone |
| CAS: | 517-23-7 |
| EINECS: | 208-235-2 |
| Type: | Pesticide; Pharmaceutical raw materials; Organic raw materials |
| Molecular Formula: | C6H8O3 |
| Molecular Weight: | 128.13 |
Chemical Properties
| Melting point | <25 °C |
| Boiling point | 107-108 °C5 mm Hg(lit.) |
| density | 1.19 g/mL at 25 °C(lit.) |
| refractive index | n20/D 1.459(lit.) |
| Fp | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | 200g/l |
| form | Liquid |
| pka | 12.00±0.20(Predicted) |
| color | Clear |
| Water Solubility | 310 g/L (20 ºC) |
| Stability: | Stable. Incompatible with strong oxidizing agents, strong bases. |
2-Acetylbutyrolactone Uses
- 2-Acetylbutyrolactone is an intermediate for the synthesis of 2,4-disubstituted pyridine. A fluorescent reagent for spectrofluorimetric determination of primary amine.
- 2-Acetylbutyrolactone was used to synthesize 3,4-disubstituted pyridine; 5- (b-hydroxyethyl) – 4-methylthiazole.
- 2-Acetylbutyrolactone is an important intermediate in the synthesis of vitamin B. It is also an intermediate for the synthesis of 3,4-disubstituted pyridine and 5-(β-hydroxyethyl)-4-methylthiazole.
- Fluorescence spectrometry
2-Acetylbutyrolactone itself has only slight fluorescence, but its derivatives show high UV fluorescence. Carbonyl group can easily react with amine to form Schiff base. It is for this reason that 2-Acetylbutyrolactone is often used to confirm the production of amines in organic synthesis. 2-Acetylbutyrolactone can also form fluorescent molecules with aromatic amines through the Japp Klingemann reaction. - Drug precursor
2-Acetylbutyrolactone is used as a precursor of many drugs, including santalene and α- Methylene- γ- Butyrolactone.
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