Description
1,1,1-Trifluoroacetone CAS 421-50-1
Quick Details
| Chemical Name: | 1,1,1-Trifluoroacetone |
| Other Name: | Three fluorine acetone; Trifluoroacetone; 1,1,1-trifluoro-2-propanon; 3,3,3-Trifluoroacetone; CH3COCF3; Methyl trifluoromethyl ketone; Trifluoromethyl methyl ketone |
| CAS: | 421-50-1 |
| EINECS: | 207-005-9 |
| Type: | Pesticide intermediates; Pharmaceutical intermediates; Organic raw materials |
| Molecular Formula: | C3H3F3O |
| Molecular Weight: | 112.05 |
Chemical Properties
| Melting point | -78 °C |
| Boiling point | 22 °C(lit.) |
| density | 1.252 g/mL at 25 °C(lit.) |
| vapor pressure | 13.62 psi ( 20 °C) |
| refractive index | n20/D 1.3(lit.) |
| Fp | −23 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform, Methanol |
| form | Liquid |
| color | Clear colorless |
| Water Solubility | Miscible |
| Sensitive | Lachrymatory |
| BRN | 1748614 |
| Stability: | Volatile |
1,1,1-Trifluoroacetone Uses
An important intermediate for synthesizing bioactive substances and antihypertensive drugs, as well as a very useful organic synthetic block and trifluoromethylation reagent.
Used for the synthesis of 2-trifluoromethyl-7azaindole from 2,6-dihalopyridine. Derived chiral imines are used for preparing enantiomeric purity through Strecker reaction followed by nitrile hydrolysis or reduction α- Trifluoromethylalanine and diamine.
1,1,1-trifluoroacetone is used as an intermediate of bioactive substances and antihypertensive drugs, as well as an effective synthetic block and trifluoromethyl reaction reagent.
1,1,1-trifluoroacetone is a general chemical reagent used to synthesize glucokinase glucokinase regulatory protein (GK-GKRP) interferon, which can be a potential target for patients with type II diabetes. The reactant of an enantioselective Cycloaddition reaction.
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