Description
Heptafluorobutyric Acid CAS 375-22-4 Quick Details
| Chemical Name: | Heptafluorobutyric Acid |
| Other Name: | Heptafluorobutyricacid; Heptafluorobutyric acid anhydride; Perfluorobutanoic acid |
| CAS: | 375-22-4 |
| EINECS: | 206-786-3 |
| Type: | Synthetic material intermediates; Organic raw materials |
| Molecular Formula: | C4HF7O2 |
| Molecular Weight: | 214.04 |
Heptafluorobutyric Acid CAS 375-22-4 Chemical Properties
| Melting point | -17.5 °C |
| Boiling point | 120 °C755 mm Hg(lit.) |
| density | 1.645 g/mL at 25 °C(lit.) |
| vapor density | 7 (vs air) |
| vapor pressure | ~10 mm Hg ( 25 °C) |
| refractive index | n20/D 1.3(lit.) |
| Fp | 120-121°C |
| storage temp. | Store below +30°C. |
| form | Powder |
| pka | pK1:0.17 (25°C) |
| Specific Gravity | approximate 1.6 |
| color | Clear colorless to faint yellow |
| PH | 1 (H2O, 20℃) |
| Water Solubility | miscible |
| Sensitive | Light Sensitive |
What is Heptafluorobutyric Acid?
Heptafluorobutyric acid, also known as perfluorobutyric acid, has the molecular formula C4HF7O2. It is a colorless liquid at room temperature, with a melting point of -17.5°C and a boiling point of 120°C. This compound has a relative density of 1.651 and a refractive index of 1.3032. Heptafluorobutyric acid has a strong acidity and an odor reminiscent of butyric acid.
Chemical Stability and Reactions
Heptafluorobutyric acid is stable under normal conditions. It can undergo various chemical reactions, including salt formation, esterification, substitution, dehydration, and reduction of alcoholic hydroxyl groups. Essentially, it is formed by replacing all hydrogen atoms in butyric acid with fluorine atoms. The industrial preparation of this acid typically involves electrochemical fluorination, starting with butyryl chloride. Water and hydrogen fluoride undergo an electrolytic fluorination reaction, followed by neutralization and acidification to obtain the final product.
Applications of Heptafluorobutyric Acid
Heptafluorobutyric acid is primarily used as a surfactant. Additionally, it serves various roles, including:
- Insecticide
- Ester catalyst
- Acidifying agent
- Organic intermediate
- Synthetic rubber component
Moreover, it acts as a chemical intermediate for new pharmaceuticals, gunpowder, and flavorings. Its derivatives are also useful in synthesizing new polymer materials and can function as organic solvents.
Uses in Analytical Chemistry
Heptafluorobutyric acid (HFBA) is valuable in analytical chemistry, particularly for detoxifying neuropeptides due to its excellent resolution properties. It is used as a volatile ion pair reagent in high-performance liquid chromatography (HPLC) and gas chromatography/mass spectrometry (GC/MS). The strong acidity of HFBA ensures that other acidic groups on biomolecules remain protonated. This characteristic allows biomolecular samples to interact effectively with organic solvents during processes like reverse phase chromatography.
The longer alkyl chain of HFBA enhances its hydrophobic properties compared to trifluoroacetic acid (TFA). As a result, HFBA is suitable for samples with greater hydrophobicity. For instance, a 0.1% solution of HFBA has been used as a mobile phase in HPLC/LC-MS protocols to detect aquatic planktonic microbial cells.
Summary
In summary, heptafluorobutyric acid is a versatile compound with significant applications in both industrial and analytical chemistry. Its ability to serve as a strong acid, surfactant, and ion pair reagent makes it a valuable tool in various scientific fields.
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