Puerarin CAS 3681-99-0

Puerarin Uses

Treatment of Diabetes

Puerarin effectively lowers blood sugar levels in diabetic patients. It enhances the expression of insulin receptor substrate (IRS-1), insulin-like growth factor (IGF-1), and insulin receptors (InsR). Additionally, it activates peroxisome proliferator-activated receptor alpha (PPARα), helping to reduce blood sugar levels. Puerarin also inhibits α-glucosidase activity, further contributing to blood sugar reduction. Studies indicate that puerarin improves insulin sensitivity and reduces insulin resistance, making it beneficial for managing type 2 diabetes. Furthermore, it can prevent diabetic retinopathy by reducing blood flow resistance in the ophthalmic artery, enhancing blood circulation, and minimizing local thrombosis. It also shows promise in treating gestational diabetes.

Anti-Tumor Effects

Puerarin has a significant inhibitory effect on tumor cell proliferation. It promotes apoptosis in tumor cells, making it a potential therapeutic agent in cancer treatment.

Protective Effect on the Liver

Puerarin protects the liver from damage caused by various factors, including alcohol. Elevated levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total cholesterol (CHOL) indicate liver damage. Studies demonstrate that puerarin treatment lowers these protein levels compared to untreated models. It also reduces pro-inflammatory cytokines, indicating its ability to alleviate alcohol-induced liver damage by regulating inflammation.

Anti-Arrhythmic and Anti-Angina Effects

Research shows that puerarin can reduce the incidence of atrial fibrillation and improve cardiac stability in animal models. It is effective in treating angina pectoris caused by coronary heart disease. Puerarin lowers heart rate and blood pressure, enhances vital signs, and reduces myocardial oxygen consumption. It also dilates coronary arteries, improves blood flow, and alleviates symptoms of ischemia. Clinical studies confirm its effectiveness in elderly patients with angina, showing improvements in various cardiovascular indicators.

Effects on the Cardiovascular System

Puerarin significantly reduces blood pressure in hypertensive animal models. It has wide clinical applications in treating cardiovascular diseases, such as angina pectoris, coronary heart disease, myocardial infarction, and hypertension. Puerarin improves blood vessel conditions and reduces cardiovascular disease incidence. Additionally, it may have therapeutic effects on retinal arteriovenous occlusion, optic atrophy, and sudden deafness.

Advantages and Limitations

Puerarin is recognized for its broad pharmacological activity, clear efficacy, and low toxicity. However, its poor fat and water solubility, along with low bioavailability, can limit its use. Recent advancements in high-biocompatible polymer materials have led to the development of various nanoformulations of puerarin, including liposomes and nanocrystals. These formulations enhance dispersion, membrane penetration, and overall bioavailability compared to traditional delivery methods.

Conclusion

With ongoing research and advancements in medical technology, the potential applications of puerarin are expanding. Its diverse therapeutic benefits position it as a valuable compound in modern medicine, promising a brighter future in clinical applications.