Isonicotinic acid CAS 55-22-1

Chemical Name:Isonicotinic acid

Appearance: White powder

Purity: 99. 0%min

Stock: In stock

Sample: Available

توضیحات

Isonicotinic acid Quick Details

Chemical Name: Isonicotinic acid
Other Name: 4-Pyridine hydroxy acid; 4-Pyridine acid; Pyridine-4-hydroxy acid; 4-pyridinecarboxylic acid; Γ-picolinic acid; Pyridine-4-carboxylic acid
CAS: 55-22-1
EINECS: 200-228-2
Type: Pharmaceutical raw materials(APIs)
Molecular Formula: C6H5NO2
Molecular Weight: 123.11

Isonicotinic acid  Chemical Properties

Melting point ≥300 °C (lit.)
Boiling point 260 °C (15 mmHg)
Density 1,47g/cm
Refractive index 1.5423 (estimate)
Fp 260°C/15mm
Storage temp. no restrictions.
Solubility 6g/l
Pka 4.96(at 25℃)
Form powder
Color yellow to tan
PH 3-4 (6g/l, H2O, 20℃)(saturated solution)
Water Solubility 5.2 g/L (20 ºC)

Isonicotinic acid Uses

  1. Isnicotinic acid is a widely used intermediate. Mainly used as isoniazid (ramiphen), terfenadine, isoniacic acid and other first-line anti-tuberculosis drugs raw materials, can also be used as preservatives, electroplating additives, photosensitizers. Resin stabilizer, PVC heat stabilizer, non-ferrous metal flotation agent, etc.
  2. Isoniazid can be obtained by condensation and melting dehydration of isoniazid and hydrazine hydrate. Isoniazid has good antibacterial effect on mycobacterium tuberculosis, good efficacy, small dosage, relatively low toxicity. It is used to treat all forms of tuberculosis. It can also be used for advanced tuberculous meningitis and other extrapulmonary tuberculosis, during the period of dissolution and spread, and during the period of improved absorption. These preparations include tablets and injections.
  3. It is used as a pharmaceutical intermediate, mainly for the production of anti-tuberculosis drug isoniazid, and also for the synthesis of derivatives such as amides, hydrazides, and esters.
  4. Isonicotinic acid, also known as pyridine 4-carboxylate, is an intermediate of the plant growth regulator Trexamine, as well as an intermediate of isoniazid, a medicinal anti-tuberculosis drug.
  5. In addition, isonicotinic acid can also be used to synthesize other organic compounds or prepare chemical materials. Examples of its applications are as follows:

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