Palmidrol CAS 544-31-0

Chemical Name: Palmidrol

CAS: 544-31-0

Ensayo: 99%min

Aspecto: Polvo blanco

Capacity: 6 ton/month

Packaging: 25 kg / drum

Muestra: disponible

Descripción

Palmidrol Quick Details

Chemical Name: Palmidrol

CAS NO: 544-31-0

Molecular formula: C18H37NO2

Palmidrol Structure:Palmidrol Structure

Molecular weight 299.49

Aspecto: Polvo blanco

Content: 98%

Propiedades típicas

Artículo Especificaciones
Active Ingredients
Assay(%, On Dried base) NLT 98.0%
Physical Control
Apariencia Fine Powder
Color White to Off-White
Identificación Positivo
Loss on Drying 1.0% Max
Residuos de ignición 0.1% Max
Particle size D(0.5): 3μm
D(0.99): 10μm
Excipients None
Chemical Control
Metales pesados NMT10 ppm
Lead(Pb) NMT1ppm
Arsenic(As) NMT1ppm
Mercury(Hg) NMT0.1ppm
Cadmium(Cd) NMT1ppm
Sulfate(SO4) NMT0.040%
Cloruro(Cl) NMT0.020%
Solvent Residual Meeting USP Standard
Microbiological Control
Total Plate Count 10,000cfu/g Max
Yeast Mold 300cfu/g Max
Coliforms 10cfu/g Max
E. Coli Negative/10g
Salmonella sp. Negative/25g
Staph Aureus Negative/10g
Pseudomonas aeruginosa Negative/25g

Palmidrol: A Natural Anti-Inflammatory and Analgesic Agent

Palmidrol, also known as PEA (Palmitoylethanolamide), is an endogenous fatty acid amide classified as a nuclear transcription factor agonist. It binds to nuclear receptors in the cell nucleus, leading to a variety of biological functions that are beneficial in managing chronic pain and inflammation. Notably, PEA targets peroxisome proliferator-activated receptor alpha (PPAR-α), a critical receptor involved in regulating inflammation and lipid metabolism.

PPAR-α and Fat Metabolism

PPAR-α is one of the three subtypes of the PPAR family, the others being PPAR-β and PPAR-γ. Predominantly expressed in organs and tissues that actively metabolize fats, PPAR-α regulates the transcription of genes involved in fatty acid oxidation. It plays a significant role in lipid uptake, oxidation, and amino acid metabolism. In broader physiological processes, PPAR-α influences hemostasis, inflammation, lipid metabolism disorders, and contributes to conditions such as atherosclerosis and coronary artery disease.

Mechanism of Action and Efficacy in Animal Studies

The mechanism of action of Palmidrol and its efficacy have been extensively validated through animal models of chronic pain and inflammation. For example, in chronic granulomatous pain models, PEA has effectively reduced mechanical pain caused by nerve sprouting. Additionally, PEA prevents the activation of ganglia, demonstrating its dual action as both an anti-inflammatory and analgesic agent. These results suggest that Palmidrol operates through multiple mechanisms to relieve pain and inflammation.

Impact on the Nervous System

In the nervous system, Palmidrol is produced as part of the body’s natural repair mechanism in response to chronic inflammation and pain. In bladder inflammation, PEA has been shown to alleviate pain caused by visceral nerve reflexes. Similarly, in the femoral nerve system, Palmidrol reduces pain perception by influencing peripheral mast cells that contribute to inflammation. By modulating these processes, Palmidrol offers significant potential in treating conditions associated with nerve-related pain.

Packaging and Storage

Embalaje: Palmidrol is packaged in paper drums, each containing two plastic bags inside, with a net weight of 25 kg per drum.

Almacenamiento: It is crucial to store Palmidrol in a well-sealed container, away from moisture and direct sunlight.

Vida útil: When properly sealed and stored, Palmidrol retains its efficacy for up to 2 years.


Manufacturing Process (Flow Chart)

  1. Palm Oil Mixed with Unsaturated Fatty Acids → Crude Palmitic Acid (via Vacuum Distillation) → Pure Palmitic Acid (via Crystallization) → Palmitoyl Chloride (via Phosgenation Reaction)
  2. Crude Palmitoylethanolamide → Purification → Filtration → Re-dissolve in Ethanol → Crystallization → Filtrate Clear Liquid → Crystallization → Filtration → Solid Vacuum Drying → Testing → Packing → Final Product (N-Palmitoylethanolamide)

Palmidrol Applications

  1. Anti-Inflammatory: Palmidrol has been shown to bind to nuclear receptors and significantly reduce inflammation. Its primary target is PPAR-α, which regulates key inflammatory pathways in the body.
  2. Pain Relief and Neuroprotection: In addition to its anti-inflammatory properties, Palmidrol also offers anti-nociceptive effects (pain relief), neuroprotective properties, and anticonvulsant activity. This makes it useful in a variety of medical conditions, especially those involving chronic pain or neurological damage.
  3. Food Additive: As an edible compound, Palmidrol is used as a raw material for food additives, offering additional benefits for enhancing health and wellness.

Enhancements for Better Readability

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  3. Transitional Phrases: Added more transitional phrases such as “for example,” “additionally,” “similarly,” “by modulating,” and “in addition to” to enhance the flow of ideas and help readers follow the logic of the content more easily.

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