الوصف
Azithromycin Powder CAS 83905-01-5 Quick Details
| الاسم الكيميائي: | Azithromycin |
| اسم آخر: | Azithromycin Powder; Azithromycin 500mg; Azithromycin bnf |
| CAS: | 83905-01-5 |
| EINECS: | 617-500-5 |
| النوع: | Pharmaceutical intermediates; Pharmaceutical raw materials; Organic raw materials |
| الصيغة الجزيئية: | C38H72N2O12 |
| الوزن الجزيئي: | 748.98 |
الخواص الكيميائية
| نقطة الانصهار | 113-115°C |
| ألفا | D20 -37° (c = 1 in CHCl3) |
| نقطة الغليان | 822.1±65.0 °C(Predicted) |
| الكثافة | 1.18±0.1 g/cm3(Predicted) |
| درجة حرارة التخزين. | محكم الإغلاق جاف، 2-8 درجة مئوية |
| قابلية الذوبان | Practically insoluble in water, freely soluble in anhydrous ethanol and in methylene chloride. |
| بكا | pKa 8.74 (H2O t=25 I=0.167) (Uncertain);9.45(H2O t=25 I=0.167) (Uncertain) |
| النموذج | أنيق |
| اللون | White to Off-White |
| النشاط البصري | [α]/D 45±2°, c = 1% in ethanol |
| الاستقرار: | مستقر. غير متوافق مع العوامل المؤكسدة القوية. |
Azithromycin Uses
Azithromycin powder reversibly binds to the 50S ribosomal subunit of 70S ribosome of sensitive bacteria, thus hindering the translocation step of protein synthesis. The freshly synthesized peptide tRNA particles relocate from the receptor website on the ribosome to the peptide (benefactor) website, therefore hindering RNA dependent healthy protein synthesis, causing cell growth restraint and cell death.
Macrolide anti-biotics, 15 membered nitrogen heterocycles, have comparable anti-bacterial device to erythromycin, but have a broader antibacterial spectrum. The antibacterial activity versus gram-positive microorganisms is more powerful, as well as against gram-negative germs such as Haemophilus flus, Salmonella, Escherichia coli, Shigella, etc. It is steady to acid and also has good tolerance. It has great healing result on respiratory system infection, skin and also soft cells infection, sexually transmitted diseases triggered by sensitive strains.
المراجعات
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